Side-by-Side: A Comparison of SSRIs, SNRIs, and Other Common Antidepressants
- David Newby
- Oct 3
- 2 min read
Updated: Oct 18
Medically reviewed
on October 18, 2025
Antidepressants come in many forms, and finding the right fit can feel daunting. This side-by-side antidepressants comparison breaks down the most common classes, what they’re used for, and what you can expect to make the decision process a little easier.
SSRI Antidepressants (Selective Serotonin Reuptake Inhibitors)
Examples: Sertraline (Zoloft), Fluoxetine (Prozac), Escitalopram (Lexapro).
Best For: The most common starting point for depression and a wide range of anxiety disorders (OCD, panic, GAD). They are generally safe and effective.
Common Side Effects: Initial nausea and headaches that often fade. More persistent issues can include sexual dysfunction (low libido, etc.) and emotional "flatness."
SNRI Antidepressants (Serotonin-Norepinephrine Reuptake Inhibitors)
Examples: Venlafaxine (Effexor XR), Duloxetine (Cymbalta).
Often Best For: Depression, anxiety, and especially chronic pain conditions like fibromyalgia or nerve pain. May be more helpful for depression accompanied by significant fatigue.
Common Side Effects: Similar to SSRIs, but can also include increased sweating, dry mouth, and a potential rise in blood pressure.
Atypical Antidepressants
These are often chosen to target specific symptoms or avoid certain side effects.
Bupropion (Wellbutrin)
Often Best For: Depression with fatigue, low motivation, and poor concentration. A key benefit is the lack of sexual side effects and weight gain. It also helps with smoking cessation.
Key Considerations: Can increase anxiety or insomnia. It is generally unsafe for individuals with seizure or eating disorders.
Mirtazapine (Remeron)
Often Best For: Depression coupled with severe insomnia and poor appetite, as its main side effects are sedation and increased appetite.
Key Considerations: Often causes significant drowsiness and weight gain.
Choosing the Best Fit: A Personalized Antidepressants Comparison
The best fit is a collaborative decision with your doctor, based on:
Your Main Symptoms: Is your biggest issue anxiety, fatigue, pain, or insomnia?
Side Effect Concerns: Are you trying to avoid sexual side effects, weight gain, or drowsiness?
Your Overall Health: Your provider will consider factors like blood pressure, seizure risk, and other medications you take.
Past Experience: How you (or a close relative) have responded to medications in the past is a very strong clue.
Antidepressants aren’t one-size-fits-all, and finding the right fit can take time, as most antidepressants need 4-6 weeks to reach their full effect. If you’re considering starting or switching, let’s find the best fit together. Wishing you continued success on your mental health journey!
Breezy Mental Health, LLC
Disclaimer: This article is for informational purposes only and should not be used as a replacement for medical advice. Always consult with a healthcare professional for accurate information for your situation.
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