SSRI vs SNRI: Antidepressant Types Comparison

Medically reviewed

by David Newby, APRN, PMHNP-BC 

on February 25, 2026

When you’re exploring treatment options for mental health, understanding the differences between medications can feel overwhelming. Two common types of antidepressants you might hear about are SSRIs and SNRIs. Both are widely prescribed and effective, but they work in slightly different ways. I want to help you feel confident and informed about these options by breaking down the key differences between SSRIs and SNRIs in a clear, straightforward way.

Let’s dive into what makes each of these antidepressants unique, how they work, and what you might expect if you or someone you know is prescribed one of them.

What Are SSRIs and SNRIs? Antidepressant Types Comparison

SSRIs, or Selective Serotonin Reuptake Inhibitors, and SNRIs, or Serotonin-Norepinephrine Reuptake Inhibitors, are both classes of medications used to treat depression and anxiety disorders. They are believed to help balance chemicals in your brain that affect mood and emotions.

• SSRIs focus mainly on increasing serotonin levels. Serotonin is a neurotransmitter believed to contribute to feelings of well-being and happiness.

• SNRIs increase both serotonin and norepinephrine. Norepinephrine is another neurotransmitter believed to influence alertness and energy.

  
  

Both types of medications can improve mood, reduce anxiety, and help with other symptoms related to depression. However, because they target different chemicals, they may have different effects and side effects.

Understanding these differences can help you have a more productive conversation with your healthcare provider about which medication might be best for your specific needs.

How SSRIs and SNRIs Work in Your Brain

The brain communicates through chemicals called neurotransmitters. It is theorized that when these chemicals are out of balance, it can affect your mood and mental health. SSRIs and SNRIs work by preventing the reabsorption (reuptake) of certain neurotransmitters, making more of them available in the brain.

• SSRIs block the reuptake of serotonin only. This means serotonin stays longer in the spaces between nerve cells, which is believed to result in it's effectiveness.

• SNRIs block the reuptake of both serotonin and norepinephrine. This dual action may provide a broader effect on mood and energy.

  
  

Because norepinephrine affects alertness and energy, SNRIs might be more helpful if you experience fatigue or low energy along with depression.

Both medications usually take several weeks to show full benefits. It’s important to be patient and keep in touch with your healthcare provider during this time.

Common Uses and Conditions Treated

Both SSRIs and SNRIs are prescribed for a variety of mental health conditions. Here’s a quick look at what they commonly treat:

• SSRIs are often used for:

- Major depressive disorder

- Generalized anxiety disorder

- Panic disorder

- Obsessive-compulsive disorder (OCD)

- Post-traumatic stress disorder (PTSD)

• SNRIs are used for:

- Major depressive disorder

- Generalized anxiety disorder

- Panic disorder

- Certain types of chronic pain (like neuropathic pain or fibromyalgia)

If you have symptoms like low mood, anxiety, or chronic pain, your provider might consider either SSRI or SNRI depending on your specific situation. Knowing the conditions each medication targets can help you understand why your provider might recommend one over the other.

Side Effects and What to Expect

Like all medications, SSRIs and SNRIs come with potential side effects. While many people tolerate them well, it’s good to know what to watch for.

Common SSRI side effects include:

• Nausea

• Headache

• Sleep disturbances (insomnia or drowsiness)

• Sexual dysfunction

• Dry mouth

  
  

Common SNRI side effects include:

• Nausea

• Dizziness

• Increased blood pressure (in some cases)

• Sweating

• Sexual dysfunction

  
  

Because SNRIs affect norepinephrine, they may sometimes cause a slight increase in blood pressure. It is important to monitor your blood pressure if you’re prescribed an SNRI.

How to Work with Your Provider to Choose Between SSRIs and SNRIs

Choosing the right antidepressant with your provider is a decision that depends on your symptoms, medical history, and lifestyle. Here are some factors to consider:

1. Symptom profile: If you struggle mainly with low mood and anxiety, SSRIs might be a good starting point. If fatigue or pain is a big part of your experience, SNRIs may be more helpful.

2. Side effect tolerance: Some people tolerate SSRIs better, while others do better on SNRIs. Often people may switch from one group to the other depending on their response.

3. Other health conditions: If you have high blood pressure, your provider might be cautious with SNRIs.

4. Previous medication response: If you’ve taken antidepressants before, your history can help guide the choice.

   
   

Remember, medication is just one part of treatment. Therapy, lifestyle changes, and support are also important.

If you want to explore more about the differences, you can check out this helpful SSRi/SNRI Comparison for a detailed overview.

What to Do When Starting Your Medication

Starting a new antidepressant can feel like a big step. Here are some tips to help you through the process:

• Follow your provider’s instructions carefully. Take your medication at approximately the same time every day.

• Be patient. It can take 4 to 6 weeks to feel the full effect.

• Keep a symptom diary. Note any changes in mood, side effects, or new symptoms.

• Stay in touch with your provider. Regular check-ins are helpful to adjust your treatment if needed.

• Avoid alcohol and recreational drugs. These can interfere with your medication and potentially increase adverse effects.

• Avoid stopping the medication suddenly. Stopping antidepressants abruptly can cause withdrawal symptoms.

  
  

Your journey to feeling better is unique. Support and communication with your healthcare team make a big difference.

Supporting Your Mental Health Beyond Medication

Medication can be a powerful tool, but it may work better alongside other strategies. Here are some ways to support your mental health:

• Therapy: Talking with a counselor or therapist can help you develop coping skills and help change patterns of thinking.

• Exercise: Regular physical activity may boost mood and energy.

• Sleep: Aim for consistent, restful sleep each night.

• Nutrition: Eating balanced meals may help support well-being.

• Mindfulness and relaxation: Practices like meditation or deep breathing can help reduce stress.

  
  

At Breezy Mental Health, we believe in personalized care that fits your life. Whether you’re starting medication or exploring other options, you deserve compassionate support every step of the way.

I hope this breakdown of SSRIs and SNRIs helps you feel more informed and empowered. Remember, the right treatment is the one that fits your unique needs and helps you move toward wellness. If you’re considering antidepressants or want to learn more, don’t hesitate to reach out to a trusted healthcare provider who can guide you with care and expertise.

Breezy Mental Health, LLC

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Disclaimer: This article is for informational purposes only and should not be used as a replacement for medical advice. Always consult with a healthcare professional for accurate information for your situation.